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24 August 2022 at 11:24:41

Process Associate


Drug Discovery/ Pre-clinical


Process Associate - Translation We are looking for a Process Associate to join the fast-growing team within our Translation unit at our site in London! This position is a full-time opportunity, on a permanent basis. Resolution Therapeutics is a biotechnology company developing macrophage cell therapies to treat inflammatory organ disease. The company's technology platform is based on over a decade's work by Prof. Stuart Forbes and Prof. John Campbell, and provides RTx with a leading position in macrophage biology and regenerative medicine. In 2020, following a productive collaboration between Edinburgh's Centre for Regenerative Medicine, the Scottish National Blood Transfusion Service, and Syncona, Resolution Therapeutics was launched with a £26.6m series A financing. Today, RTx is a multidisciplinary team of experienced scientists, engineers and entrepreneurs based in Edinburgh and London, working at the forefront of cell therapy and liver disease, supported by Syncona, Europe's leading life science investor. In this role you will In this role you will support the day-to-day development of a process to produce genetically engineered macrophages for therapeutic applications in inflammatory organ damage. You will work very closely with the Scottish National Blood Transfusion Service (SNBTS), with which Resolution has partnered to deliver gene-modified macrophage cell therapy for clinical use, to develop a GMP-compliant process Key responsibilities:

Supporting optimisation of established processes suitable for transfer to GMP manufacturing environment for engineered macrophage cell therapy and contribute to SOP development for these procedures
Contributing to analysis of data for use in project reports and presentations
Working closely with Cell Engineering, Macrophage Biology and stem cell units to perform technology transfer from research to GMP-compliant processes
Liaising with external contributors and collaborators for harmonisation of workflows and procedures
Maintaining a clean laboratory environment including stock and inventory checks of process specific consumables
Contributing to Translation activities required for dossier development
Maintaining good documentation practices for data recording
Liaising with external vendors and suppliers

Please note that this list is not exhaustive You will be expected to work as part of a team with Process Scientists as well as others within and beyond the Translation unit, reporting directly to the Group Leader The successful candidate must have the following qualifications, skills, and experience:

A bachelor's degree in Biology, Biotechnology, or a related discipline
Experience in Good Manufacturing Practice (GMP)/Good Clinical Laboratory Practice (GCLP) settings
Experience in cell therapy process development or manufacture
Experience with different primary cell cultures and different culture systems including differentiation and/or proliferation
Experience using the CliniMACS Prodigy instrument and/or similar equipment
Experience using bioreactors
Proven ability to work productively within a team as well as the ability to take initiative and work independently
Excellent time management and organisation
Confidence to communicate effectively and clearly both verbally and in writing
Ability to maintain accurate and up to date records

Preferable skills / experience include:

A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease
Experience in cell therapy process analytics
Experience with multicolour cell flow cytometry and associated data analysis
Experience with ELISA and MSD
Experience with molecular techniques, such as PCR
Understanding of Quality Management Systems
Experience in a commercial laboratory environment and/or a small biotechnology company focussed on cell therapy/ATMP development

Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company's incentive shares scheme. Selection process: Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:

Initial meeting with the Hiring Manager and another member of the RTx team
Presentation & panel interview
Conversation with the CEO

Please be aware that due to the volume of applications, feedback will not be provided at the application stage. Please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat (). <img src="">

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