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24 August 2022 at 11:24:41

Analytical Associate




Analytical Associate - Translation We are looking for an Analytical Associate to join the fast-growing team within our Translation unit at our site in London! This position is a full-time opportunity, on a permanent basis. Resolution Therapeutics is a biotechnology company developing macrophage cell therapies to treat inflammatory organ disease. The company's technology platform is based on over a decade's work by Prof. Stuart Forbes and Prof. John Campbell, and provides RTx with a leading position in macrophage biology and regenerative medicine. In 2020, following a productive collaboration between Edinburgh's Centre for Regenerative Medicine, the Scottish National Blood Transfusion Service, and Syncona, Resolution Therapeutics was launched with a £26.6m series A financing. Today, RTx is a multidisciplinary team of experienced scientists, engineers and entrepreneurs based in Edinburgh and London, working at the forefront of cell therapy and liver disease, supported by Syncona, Europe's leading life science investor. In this role you will support the day-to-day development and implementation of assays and analytics characterising genetically engineered macrophages for therapeutic applications in liver cirrhosis. You will work very closely with the Scottish National Blood Transfusion Service (SNBTS), with which Resolution has partnered to deliver gene-modified macrophage cell therapy for clinical use, to develop a GLP-suitable process.
Key responsibilities: · Execution of day-to-day in-process and final product analytical testing required during the process development projects of the Translation group, with focus on cell count, flow cytometry, cell-based functionality assays/co-cultures, proliferation assays, qPCR and metabolic assays. · Execution of study protocols for the development of assays and analytics to assess and confirm cell-based product characteristics, including flow cytometry, ELLA, MSD, cell imaging, primary cell culture and co-cultures · Execution of study protocols for the development of assays and analytics to assess molecular-based product characteristics, including qPCR to assess product purity and gene expression levels, plasmid copy number and karyotyping · Assist in the establishment, development and execution of stability studies · Provide input to the compilation of study protocols and reports associated with the development or characterisation of a cell-based or molecular assay · Provide input to the documentation for qualification or validation of assays · Interfacing with the Cell Engineering and Macrophage Biology Units to support the translation of research protocols and support development of standard operating procedures for the GLP environment Please note that this list is not exhaustive You will be expected to work as part of a team with Analytical Scientists and others both within and beyond the Translation unit, reporting directly to the Group Leader. The successful candidate must have the following qualifications, skills, and experience: · A Bachelor degree in Biology, Biochemistry or a related discipline · Experience in analytics, including with gene-modified cell therapy products · Experience in Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) settings · Proven track record in development and validation of cell and gene-based assays · Experience with cell flow cytometry, the associated data analysis · Experience with ELISA · Experience with primary cell culture and coculture systems · Experience with molecular techniques, such as qPCR · Proven ability to work productively within a team · Ability to take initiative and work independently · Ability to maintain accurate and up to date records
Preferable skills / experience include: · A working knowledge of immunology and chronic inflammatory diseases, preferably chronic liver disease · Experience developing cell therapies · Experience using the CliniMACS Prodigy instrument and associated equipment · Experience in a commercial laboratory environment/small biotechnology company with a focus on developing cell therapies or ATMPs
Benefits: Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company's incentive shares scheme.
Selection process: Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:

Initial meeting with the Hiring Manager and another member of the RTx team
Presentation & panel interview
Conversation with the CEO

Please be aware that due to the volume of applications, feedback will not be provided at the application stage. Please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat (). <img src="">

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