We are looking for a Research Scientist to join the fast-growing team within our Macrophage Biology unit at our site in Edinburgh! This position is a full-time opportunity, on a permanent basis.
Resolution Therapeutics is a biotechnology company developing macrophage cell therapies to treat inflammatory organ disease. The company's technology platform is based on over a decade's work by Prof. Stuart Forbes and Prof. John Campbell, and provides RTx with a leading position in macrophage biology and regenerative medicine.
In 2020, following a productive collaboration between Edinburgh's Centre for Regenerative Medicine, the Scottish National Blood Transfusion Service, and Syncona, Resolution Therapeutics was launched with a £26.6m series A financing.
Today, RTx is a multidisciplinary team of experienced scientists, engineers and entrepreneurs based in Edinburgh and London, working at the forefront of cell therapy and liver disease, supported by Syncona, Europe's leading life science investor.
In this position, you will take a lead role in developing a study to test enhanced macrophage products for cell therapy for liver cirrhosis. You will be expected to conduct original research relevant to the aims of the project, transfer SOPs and knowledge to fellow researchers of the group and the process development team and produce material for patenting and publication.
· Screening genetically modified (GM) macrophages using functional in vitro assays.
· Establish new cell-based assay according to the project need and priorities.
· Write SOPs for the work carried out to be transferred to the process development team.
· Interface with the Cell Engineering, iPSC-derived Macrophage, and In Vivo Pharmacology units to characterise the best-in-class iPSC-derived macrophage products, and define their efficacy and safety profiles.
· Work with academic collaborators to model data, identifying what key functions in vitro are predictors of efficacy in vivo.
· Help collecting and interpreting data to assess the immunogenic potential of iPSC-derived macrophages.
· Interface with process development and analytical development teams to implement analytics under GMP conditions for testing of GM macrophages for clinical use.
· Writing patents, publications, and summarising data for progress reports
Please note that this list is not exhaustive
You will be expected to work as part of a team with like-minded Research Scientists and Research Associates, reporting directly to Kayleigh Thirlwell.
The successful candidate must have the following qualifications, skills, and experience:
· A PhD in cell biology/immunology
· Proven track record of independent manuscript publication and/or patent submission
· Ability to maintain accurate and up to date records
· Solid experience with primary immune cell culture, preferably monocytes/macrophages
· Demonstrable experience in conducting cell biology assays such as co-coltures, cell migration and cell invasion assays
· Proven experience with antibody-based sorting and analysis using flow cytometry and magnetic bead separation (MACS or similar)
· Strong experience in western blotting, nucleic acid isolation and purification, qPCR, ELISA assays, microscopy, histology
Preferable skills / experience include:
· A working knowledge of chronic inflammatory diseases
· Familiarity with the principles of Good Clinical Practice (GCP) and Good Manufacturing Practice (GMP)
· Knowledge of process development and analytics
· Experience in a commercial laboratory environment
· Experience in working with rodent models
· Home Office Personal Licence (PIL)
Our competitive package includes income protection, pension, private health insurance, and life assurance, as well as an opportunity to participate in the Company's incentive shares scheme.
Following your application, an initial call will be scheduled by the Recruitment Partner before being shortlisted. If successful, you will be invited to start the interview process which consists of 3 stages:
- Initial meeting with the Hiring Manager and another member of the RTx team
- Presentation & panel interview
- Conversation with the CEO
Please be aware that due to the volume of applications, feedback will not be provided at the application stage.
Please direct any questions and CVs in the first instance to our Recruitment Partner at Life Science People, Poppy Boronat ().