The company unites technology with human intelligence to re-engineer drug discovery and deliver life-changing medicines. They have developed a drug discovery platform built on powerful data foundations with state-of-the-art machine learning and AI technology. Our technology empowers scientists to decipher the vast and complex code underlying human biology, find new ways to treat disease and personalise medicines to patients. The company has active in-house R&D drug programmes in disease areas such as neurodegeneration, immunology, oncology and inflammation and has research and commercial collaborations with leading pharmaceutical and research organisations. The company is headquartered in London with a research facility in Cambridge (UK) and a further office in New York.
Who they are?
Their mission is to re-engineer drug discovery and deliver life-changing medicines for patients in need and they do this by applying AI, machine learning and other advanced technologies to reinvent the ways drugs are discovered and developed. We strive to bring together unique skills and perspectives across biology, chemistry, engineering, AI research, informatics, precision medicine and drug discovery.
This is an exciting role within the company's In Vivo group where you will apply your experience as an in vivo pharmacologist and project representative to help projects drive to achieve key milestones. As a central member of a dynamic, multi-disciplinary team of scientists passionate about developing medicines, you will act as in vivo pharmacology lead on multiple projects supporting in vivo PD models and target engagement. Working cohesively with In Vitro colleagues, using your theoretical and practical expertise, you'll take a hands-on approach in the development of disease models, management of studies and analysis of results through histology, molecular and biochemical profiling, you will establish assay systems and deliver datasets that will have a direct impact on project progression.
- Within the project team, serves as a scientific expert contributing at a high level across in vivo pharmacology activities, including supporting translational efficacy models, TE and biomarker strategy, study design, implementation and interpretation.
- Developing a deep understanding of disease mechanism and target biology, participating in broader project strategy and decision making.
- With a comprehensive understanding of all aspects of study design and implementation, you will be responsible for establishing strong cross-functional relationships with PK/PD and TE stakeholders, resulting in cohesion and clarity in the delivery of studies and the presentation of decision-making data.
- Where required, coordinating in vivo studies in multiple projects across the portfolio to ensure high quality, efficiency and timely delivery of studies whether external or internal.
- You will also have the opportunity to work with other In Vivo project reps to support target identification disease deployments.
- Ability and willingness to perform and teach most common regulated procedures: animal handling, routes of administration of test agents e.g. ip, iv, sc, blood collection, necropsy and preparation of tissue for histology, molecular or biochemical profiling, collection of data when needed would be an advantage.
We are looking for someone with
- PhD or Degree qualified with extensive experience of working in a vivarium and leading in vivo research activities. Significant experience working as a functional lead on project teams, ideally to preclinical development and with experience writing reports and documentation to support regulatory filing.
- Experience of working closely with PK/PD and in vitro biology leads within project environments, and ideally with a good understanding of drug delivery and PK in relation to PD.
- An in-depth understanding of a therapy area such as neuroscience, oncology, metabolic diseases, drug safety etc would be valuable.
- Current or previous Personal Home Office Licence holder (modules 1-4/A-C, with Module 5 being desirable).
- A good understanding of integrated physiology, pathophysiology and in vivo practice and procedures. Wide-ranging experience in designing, directing and implementing in vivo experiments to respond to key research and pharmacodynamic questions.
- Track record of significant contributions to the achievement of important scientific decisions or milestones on projects.
- Experience of working with external KOL and/or CROs is desirable.
- Excellent communication skills.